In conclusion, ECV can be measured from three samples almost as accurately as ECV from multiple samples. Total body water was measured using the nonradioactive isotope, deuterium oxide extracellular fluid volume was assayed using the nonradioactive isotope. ECV6 iohexol correlated slightly better with ECV6 EDTA (ECV6 EDTA = 0.81.ECV6 iohexol + 3.3 L r = 0.86) than with ECV3 EDTA (ECV3 EDTA = 0.83.ECV6 iohexol + 2.9 L r = 0.84) and had slightly narrower 95% limits of agreement (−3.82 and 2.82 L versus −3.90 to 3.43 L). ECV6 EDTA correlated closely with ECV3 EDTA (ECV3 EDTA = 1.01.ECV6 EDTA–0.5 L r = 0.97 n = 99), but less closely with Vd ( Vd = 1.17.ECV6 EDTA + 0.7 L r = 0.86). The precision of a simplified single injection method for determination of the distribution volume of 51Cr EDTA, as an estimate of the extracellular fluid. ECV (ECV3) was calculated by dividing GFR3 by GFR/ECV3, having corrected both for their one-compartment assumptions. Because the extracellular fluid is composed primarily of NaCl and water (with some NaHCO3 and some potassium. Slope-intercept GFR was calculated from the last three samples using the slope-intercept technique (GFR3). The term ‘volume, as used here, is used to describe extracellular fluid volume. The most abundant electrolyte in extracellular fluid is sodium. GFR/ECV was calculated as the rate constant of the exponential fitted to the last three samples (GFR/ECV3). Extracellular fluids (ECF) are fluids found outside of cells. and whether decreased ECF volume will produce thirst in the absence of ICF volume changes. Reference ECV (ECV6) was calculated from all six samples as the product of indicator transit time and multi-sample GFR. There are four intrinsic mechanisms that work closely together to maintain ECF volume and, transiently, blood pressure: the. The other determinants of blood pressure are cardiac output (heart rate × stroke volume) and total peripheral resistance. Blood samples were obtained bilaterally 20, 40, 60, 120, 180 and 240 min post-injection and assayed for indicator injected contralaterally. The volume of the ECF is a major determinant of blood pressure. GFR and ECV were measured using Cr-51-EDTA and iohexol injected into opposite arms in 51 patients undergoing routine measurement of GFR and on 48 occasions in 20 healthy volunteers. The aim was to validate a new technique for measuring ECV from the slope-intercept approach. The zero-time distribution volume ( Vd) generated in the slope-intercept technique for measuring the glomerular filtration rate (GFR) substantially overestimates ECV. Extracellular fluid volume (ECV) is studied infrequently.
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